Scientific Hypotheses – Michigan Paranormal Encounters http://michiganparanormalencounters.com/ Fri, 16 Jul 2021 04:39:15 +0000 en-US hourly 1 https://wordpress.org/?v=5.7.2 http://michiganparanormalencounters.com/wp-content/uploads/2021/06/icon-2.png Scientific Hypotheses – Michigan Paranormal Encounters http://michiganparanormalencounters.com/ 32 32 Confused debate over origin of COVID-19 distracts attention from actual research http://michiganparanormalencounters.com/confused-debate-over-origin-of-covid-19-distracts-attention-from-actual-research/ http://michiganparanormalencounters.com/confused-debate-over-origin-of-covid-19-distracts-attention-from-actual-research/#respond Thu, 15 Jul 2021 22:48:00 +0000 http://michiganparanormalencounters.com/confused-debate-over-origin-of-covid-19-distracts-attention-from-actual-research/ Illustration by Qianli From genetic signatures to personal testimonies, evidence is growing to support the theory that the COVID-19 virus emerged from nature, while the hypothesis of a laboratory leak remains unfounded, according to studies and scientists. Last week, 21 scientists from universities and research institutes around the world published a critical review on the […]]]>

Illustration by Qianli

From genetic signatures to personal testimonies, evidence is growing to support the theory that the COVID-19 virus emerged from nature, while the hypothesis of a laboratory leak remains unfounded, according to studies and scientists.

Last week, 21 scientists from universities and research institutes around the world published a critical review on the possible origins of SARS-CoV-2 on the Zenodo preprint server. The paper, which is still pending peer review, reviewed the existing scientific literature on both hypotheses.

Citing the history of emerging diseases, epidemiological data and genomic information, he concluded that a substantial body of scientific evidence points to a zoonotic origin of the virus, while there is currently no credible evidence of a leak of the virus. laboratory. The Wuhan Institute of Virology in Hubei Province has been touted by some Western scientists and governments as a possible source of the coronavirus.

“There is no evidence that the first cases had a connection to the Wuhan Institute of Virology, nor any evidence that the WIV owned or worked on an ancestor of SARS-CoV-2 before the pandemic,” says the study. He added that the lab leak hypothesis stems from the coincidence that the virus was first detected in Wuhan, where a large lab that studies coronaviruses is located.

The problem with the lab leak hypothesis is that it’s almost impossible to verify or disprove. As it cannot be conclusively ruled out, room is left for doubt and speculation, according to the study. However, focusing on an unlikely lab leak scenario distracts scientists from more serious and urgent research. “Failure to thoroughly investigate the zoonotic origin through collaborative and carefully coordinated studies would leave the world vulnerable to future pandemics,” the study said.

On July 5, a study by Chinese scientists posted to the bioRxiv preprint server looked at the mutation spectrum of SARS-CoV-2 and found it to be 99.9% identical to that of RaTG13, the closest relative. of the COVID-19 virus detected so far. . RaTG13 is found in horseshoe bats.

In addition, the mutation spectrum of SARS-CoV-2 is 99.3% identical to that of RshSTT182, another close relative of the COVID-19 virus found in a different species of horseshoe bats in Southeast Asia. South East.

These results indicate that SARS-CoV-2 evolved in a host environment – very similar, if not identical, to RaTG13 and other bat coronaviruses – that is difficult to duplicate under arbitrary cell culture conditions in laboratory, according to the study.

Overall, the international scientific community leans towards the idea that the COVID-19 virus has passed from animals to humans, possibly via an unidentified intermediate host.

However, the hypothesis of a laboratory leak has been rekindled as foreign politicians and media claim that staff at the Wuhan institute had flu-like symptoms and may have been infected with COVID. -19 in November 2019. The claims were based on an unverifiable intelligence report.

In June, Australian virologist Danielle Anderson, the only foreign scientist working at the Wuhan lab before the outbreak, told Bloomberg that no one she knew in the lab was sick at the end of 2019.

The institute had set up a procedure for reporting symptoms related to pathogens handled in the laboratory. “I was tested for the coronavirus in Singapore before I was vaccinated and had never had it,” Anderson said.

She added that many of her colleagues from Wuhan traveled to Singapore at the end of December 2019 for a meeting on the Nipah virus and that there was no mention of any disease sweeping the institute.

Tong Yigang, president of the College of Life Sciences and Technology at Beijing University of Chemical Technology, told a press briefing in March that rumors of three institute staff members were falling ill was the result of another poorly reported incident. These were actually positive COVID-19 test samples from a hospital that were submitted to the lab for research, he said.

Tong, who was a member of the WHO mission to China to investigate the origin of COVID-19, said the team investigated the rumor and found that no staff at the institute had been sick.

In 2019, the institute and a hospital in Wuhan collaborated to monitor influenza epidemics. From January 2019 to January 2020, scientists collected 1,001 samples and submitted them to the lab for research in March 2020. They found that four samples collected in January 2020 were positive for influenza and COVID-19. “They were hospital patients, not WIV staff (members),” Tong said.

“Science, not speculation”

Last week, two dozen scientists published an open letter in the medical journal The Lancet stating that SARS-CoV-2 most likely came from nature and not from a laboratory, based on a genetic analysis of the new viruses and well-established evidence of other coronavirus-related illnesses.

“Science, not speculation, is essential in determining how SARS-CoV-2 reached humans,” the scientists said. “It’s time to lower the heat of rhetoric and turn on the light of scientific research.”

David Relman, professor of microbiology and immunology at Stanford University in the United States, told an online seminar last week that one of the reasons for the natural overflow and leakage hypotheses of laboratory are both contemplated is that the “immediate ancestors” and “intermediate host” for the virus are still unknown.

He added that more research should be done to anticipate the next pandemic and create a more effective response.

Relman said it was troubling that the investigation into the origin of the virus had become deeply politicized. It has come to a point where it is “reckless and unnecessary” to share an opinion on the origin, as many people have strong opinions on the most likely scenario, he said.

A Beijing-based microbiologist, who spoke on condition of anonymity, said the discussion of the origin of the virus had become “chaotic and toxic” due to scant data, a lack of confidence in existing scientific investigations and of some foreign politicians blaming China for political reasons.

“Scientists have debated a range of original hypotheses since the start of the epidemic, and the origin associated with the laboratory was neither new nor convincing,” the expert said.

“In high science, ideas are swept up and flipped all the time – it’s a messy and error-prone process. But, a good quality of rational scientists is that they are willing to self-correct and change your mind when new evidence is presented. “

The microbiologist added: “The politicians and the media that launch all the new findings and opinions will only make public discourse on the origin of the virus more confusing and frustrating.”


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Changing demographics of medical researchers doing kidney research in the United States http://michiganparanormalencounters.com/changing-demographics-of-medical-researchers-doing-kidney-research-in-the-united-states/ http://michiganparanormalencounters.com/changing-demographics-of-medical-researchers-doing-kidney-research-in-the-united-states/#respond Wed, 14 Jul 2021 21:03:11 +0000 http://michiganparanormalencounters.com/changing-demographics-of-medical-researchers-doing-kidney-research-in-the-united-states/ Strong points In the United States, the workforce of medical scientists performing kidney research is increasingly made up of women and international medical graduates. However, this workforce is older, declining in relative numbers, and is less heavily focused on basic science than clinical science. Washington, DC (July 14, 2021) – America’s medical scientists are making […]]]>

Strong points

  • In the United States, the workforce of medical scientists performing kidney research is increasingly made up of women and international medical graduates.
  • However, this workforce is older, declining in relative numbers, and is less heavily focused on basic science than clinical science.

Washington, DC (July 14, 2021) – America’s medical scientists are making huge contributions to biomedical research. New Research Published in CJASN Shows Growing Representation of Women and International Graduates in the Physician-Scientist Workforce in Renal Research; however, this workforce is shrinking in relative numbers, aging, and less heavily focused on basic scientific research.

The research was based on public data obtained from the Internet. A team led by Susan M. Wall, MD (Emory University School of Medicine) extracted records from the National Institutes of Health (NIH) to explore demographic shifts in early career and established principal investigators, physicians and non-physicians doing research. NIH-focused kidney research funded between 1990 and 2020.

The researchers found that lead researchers focused on the kidneys are getting older, especially among doctors. In addition, the relative representation of physicians among early career investigators and established principal investigators is declining, particularly among those engaged in basic scientific research. In contrast, the number and relative representation of non-medical scientists is increasing. There is also a greater representation of women and international graduates among medical and non-medical kidney researchers; however, female physician scientists are increasingly likely to do clinical rather than basic research.

“Physician-researchers are in a unique position to formulate testable hypotheses that are clinically relevant. Research training also provides a useful perspective when evaluating human disease in the clinic, ”said Dr. Wall.

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Study co-authors include Delaney C. Abood, Spencer A. King, and Douglas C. Eaton.

Disclosures: DC Eaton reports receiving honoraria from the National Institutes of Health and the University of Pittsburgh; patents and inventions with the monograph “Vander’s Renal Physiology” McGraw Hill Publishing; and as a scientific advisor or member of the editorial boards of the American Journal of Physiology-Renal Physiology and APSselect. SM Wall declares that he owns shares in Abbott, Becton Dickinson, Johnson and Johnson, Merck, Roche and Thermo Fisher; SM Wall has no stock options. SM Wall claims to have been a representative of the American Physiological Society on the FASEB Finance Committee.

The article, entitled “Changing Demographics of NIDDK-Funded Physician-Scientists Doing Kidney Research”, will appear online at http: // cjasn.newspapers.org / on July 14, 2021, doi: 10.2215 / CJN.02440221.

The contents of this article do not reflect the views or opinions of the American Society of Nephrology (ASN). Responsibility for the information and opinions expressed therein rests entirely with their author (s). ASN does not offer medical advice. All the content of ASN publications is provided for informational purposes only and is not intended to cover all the uses, directions, precautions, drug interactions or possible adverse effects. This content should not be used in a medical emergency or for the diagnosis or treatment of any medical condition. Please consult your doctor or other qualified health care provider if you have any questions about any medical condition or before taking any medication, changing your diet, or starting or stopping any treatment. Do not ignore or delay obtaining professional medical advice because of the information accessible via ASN. Call 911 or your doctor for all medical emergencies.

Since 1966, ASN has led the fight to prevent, treat and cure kidney disease across the world by training health professionals and scientists, advancing research and innovation, communicating new knowledge and advocating for the highest quality patient care. ASN has more than 21,000 members representing 131 countries. For more information visit http: // www.asn-online.organization.

Warning: AAAS and EurekAlert! are not responsible for the accuracy of any press releases posted on EurekAlert! by contributing institutions or for the use of any information via the EurekAlert system.


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Coronavirus Company News Summary – NRx Pharmaceuticals and IIBR Collaborate on the Development of a Covid-19 Vaccine http://michiganparanormalencounters.com/coronavirus-company-news-summary-nrx-pharmaceuticals-and-iibr-collaborate-on-the-development-of-a-covid-19-vaccine/ http://michiganparanormalencounters.com/coronavirus-company-news-summary-nrx-pharmaceuticals-and-iibr-collaborate-on-the-development-of-a-covid-19-vaccine/#respond Tue, 13 Jul 2021 08:03:32 +0000 http://michiganparanormalencounters.com/coronavirus-company-news-summary-nrx-pharmaceuticals-and-iibr-collaborate-on-the-development-of-a-covid-19-vaccine/ NRx Pharmaceuticals, a clinical-stage pharmaceutical company, has signed a memorandum of understanding with the government of Israel to authorize the exclusive global development, manufacture and commercialization of the Covid-19 vaccine developed by the Israel Institute of Biological Research (IIBR) . The BriLife vaccine is based on a previous vaccine platform, approved by the United States […]]]>

NRx Pharmaceuticals, a clinical-stage pharmaceutical company, has signed a memorandum of understanding with the government of Israel to authorize the exclusive global development, manufacture and commercialization of the Covid-19 vaccine developed by the Israel Institute of Biological Research (IIBR) . The BriLife vaccine is based on a previous vaccine platform, approved by the United States Food and Drug Administration, which has been optimized by the IIBR. The vaccine should initially be given by traditional injection.

Moderna has reached an agreement with the Argentine government to provide 20 million doses of Moderna’s Covid-19 vaccine or its updated booster variant, if allowed. Delivery of doses is expected to begin in the first quarter of 2022. The company said it continues to commit to making its Covid-19 vaccines available to the world as it seeks to end the pandemic through efforts to vaccination.

BioNTech announced that Fosun Industrial, a 100% subsidiary of its partner Shanghai Fosun Pharmaceutical, has entered into advance supply agreements to supply its mRNA-based Covid-19 vaccine with Taiwan Semiconductor Manufacturing Co., Hon Hai, the Yonglin Charitable Foundation and Zuellig Pharma, respectively. Fosun Industrial will sell a total of 10 million doses of vaccine to Zuellig Pharma. These Covid-19 mRNA vaccines will support local vaccination after being donated to the relevant disease control agency in Taiwan.


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Sequences deleted from SARS-CoV-2 at start of Wuhan outbreak offer clues http://michiganparanormalencounters.com/sequences-deleted-from-sars-cov-2-at-start-of-wuhan-outbreak-offer-clues/ http://michiganparanormalencounters.com/sequences-deleted-from-sars-cov-2-at-start-of-wuhan-outbreak-offer-clues/#respond Thu, 08 Jul 2021 20:25:33 +0000 http://michiganparanormalencounters.com/sequences-deleted-from-sars-cov-2-at-start-of-wuhan-outbreak-offer-clues/ Coronaviruses collect changes in their genetic sequences as they replicate, and studying these changes in the sequences collected over time helps scientists trace the history of the virus. Bloom therefore examined the genomic sequence reports of the virus from people infected early on to reveal patterns of its evolution. He didn’t find much at first. […]]]>

Coronaviruses collect changes in their genetic sequences as they replicate, and studying these changes in the sequences collected over time helps scientists trace the history of the virus.

Bloom therefore examined the genomic sequence reports of the virus from people infected early on to reveal patterns of its evolution. He didn’t find much at first.

Then he found an article referring to a sequence data set he hadn’t seen mentioned anywhere else. However, when he searched for these sequences in the most likely online data archives, he did not find them.

He knew that researchers can request the removal of footage they uploaded to the archives. Realizing that the data can be saved online, it deduces the corresponding URLs and finds files related to the sequences still present on the Google Cloud.

“I was able to determine that the deleted data corresponded to a study that partially sequenced 45 nasopharyngeal samples of [Wuhan] ambulatory patients suspected of COVID-19 at the start of the epidemic, ”he said. tweeted.

Combined with other clues, he eventually found 241 data files that had been downloaded and then deleted from the database. Taken together, these files represented portions of 34 early SARS-CoV-2 samples that were not previously known. But each file only included a portion of the complete sequencing information for each sample.

In the end, Bloom reconstructed enough data to examine the partial sequences of 13 early cases of SARS-CoV-2.

What the footage shows about the start of the Wuhan epidemic

The 13 reconstructed sequences do not transform what is known about the early stages of the Wuhan outbreak, and information is lacking on when and where the samples were collected. Still, they help fill in some details that bring us closer to identifying the original overflow event.

First, the data adds to other evidence that the seafood market in Wuhan was not where the virus passed from animals to humans.

Nature News wrote: “The first virus streaks from Wuhan come from individuals linked to the city’s Huanan seafood market in December 2019, which was initially believed to be where the coronavirus first passed from animals to the city. humans. But the seafood market sequences are further removed from the closest relatives of SARS-CoV-2 in bats – the most likely ultimate origin of the virus – than subsequent sequences, including one collected in the United States. . “

Columbia University epidemiologist Dr W. Ian Lipkin told the Washington post that Bloom’s document offers “evidence of what many of us speculated – that the virus was circulating before the market outbreak.” The retraction of sequence data is unprecedented and needs to be corrected. “

Lipkin told USA Today that “this line of inquiry can help us determine the origin of the virus and reconstruct how it spread in the early days of the pandemic.”

Dr Sudhir Kumar, an evolutionary geneticist at Temple University, told Nature News: “It seemed to me that the Wuhan market was one of the first super-broadcast events.

Kumar added that the footage “suggests that SARS-CoV-2 developed great diversity in the early stages of the pandemic in China, including Wuhan.”

Scientists need to find more of these missing pieces from the first outbreak to draw conclusions about the origins of the virus.

“Maybe our picture of what was present at the start of Wuhan from what was sequenced could be somewhat skewed,” Bloom told the New York Times.

No direct evidence for either theory of origin

Bloom is one of 17 experts who wrote a letter published May 13 in Science calling for an investigation into the onset of the pandemic, with a more balanced view considering all possibilities, including transmission from animals to humans – which occurs produced in many new infectious diseases – such as as well as a laboratory accident.

These new data don’t tip the scales in one theory or another, he said.

“These data provide no direct evidence for a lab accident or natural zoonosis,” Bloom said via email, with further explanation. in a Twitter thread. “However, they do indicate the importance of continuing to search for new data on the origins and early spread of SARS-CoV-2.”

He says Science that it is vital for scientists to put aside prejudices about the origins of the virus and to study this question with transparency:

“So many people have agendas and preconceptions on this topic that if you open your mouth on the topic, someone is going to take what you said to support or reject a particular narrative. So the choices are either to say nothing at all, which I don’t think is helpful or productive, or to just try to draw the possible conclusions and make them as transparent as possible. No matter how much people love [my new study] or whether they don’t like it, whether they agree with the interpretation or disagree with the interpretation, they can at least go download it and rehearse it themselves.

Reasons for deletion

In a media statement, the National Institutes of Health – which operates the archive that once housed the sequence data – explained the process of removing the footage at the request of the scientist who submitted it.

“The requester indicated that the sequence information had been updated, was submitted to another database and wanted the data to be deleted from SRA (Sequence Read Archive) to avoid version control issues,” said the NIH in its press release, reported by USA Today. “Submitting investigators own the rights to their data and can request that the data be removed. ”

These reasons were cited in a NIH email sent to Bloom, which he included in his updated prepublication. However, Bloom noted that he had found no indication that the footage had in fact been uploaded to another database, as the authors claimed.

Newly discovered, but not new

Some pointed out that the footage is not new and was not really hidden, since it was available in an article published in the journal. Small.

Nature News reported:

Stephen Goldstein, a virologist at the University of Utah in Salt Lake City, points out that the sequences Bloom picked up were not hidden: they are described in detail, with enough information about the sequences to know their evolutionary relationship. with other early SARS-CoV-2. sequences, in the Small paper. “I don’t think this preprint tells us much new, but it brings to the fore the sequence data that has been publicly available, albeit under the radar,” Goldstein said.

Bloom says it doesn’t matter that the data is not new; rather, the fact is that people analyzing other SARS-CoV-2 sequences could not find them.

“In the revised manuscript, I… specify that I cannot determine the motivations of the authors. However, I note that I did not find any websites with updated data, and the practical consequence of deleting was that no one was aware of the existence of the data, ”Bloom tweeted.

And after

Bloom said BBC Science in action, “I hope that if this article contributes to that discussion, it reminds scientists that we perform better if we search for data and try to analyze data, and we perform less well if we yell at each other about different positions. with very little evidence.

To that end, he is researching other sequences of the start of the pandemic, and he hopes other scientists will join the effort.

the The Wall Street Journal reported that other scientists share his interest.

“This makes us wonder if there are other sequences like this that have been purged,” said Dr. Vaughn S. Cooper, evolutionary biologist at the University of Pittsburgh.

Bloom posted the data he found online to encourage others to do their own analysis.

“We really need to look carefully and see if there is any other early information about the footage that was not found,” he told the the Wall Street newspaper. “I intend to go through all the first preprints I can find on SARS-CoV-2 and see if they describe data that is not in the databases.”

He keeps an open mind about how what is found can change our understanding of the pandemic, just like other scientists.

“We should, however, be prepared to revise these ideas and hypotheses further if and when earlier sequence data emerges,” Dr. Sergei Pond, professor of biology at Temple University. tweeted, calling Bloom’s pre-publication “an important piece of forensic bioinformatics.” He added: “I wouldn’t be surprised if these revisions are very significant (eg timing of introduction).”

Bloom argues that while understanding the origins and early spread is a scientific matter, policymakers must also help by enabling better investigations and greater transparency in the search and analysis of all possible data.

“We need to understand how SARS-CoV-2 started, because the response will have implications for mitigating pandemics in the future,” Bloom said. “The question of the origins of COVID-19 does not go away. It’s important that scientists look at the problem to make sure we’ve done everything we can to explore this. ”



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Relentless pursuit of justice through science http://michiganparanormalencounters.com/relentless-pursuit-of-justice-through-science/ http://michiganparanormalencounters.com/relentless-pursuit-of-justice-through-science/#respond Mon, 05 Jul 2021 15:18:00 +0000 http://michiganparanormalencounters.com/relentless-pursuit-of-justice-through-science/ ” style =”margin: 5px 15px 0 0px; border: 1px solid # 999; width: 150px;”/> Nathan Boulanger In 1998, Joyce Rita Hayman was convicted of criminal negligence and administration of a noxious substance, based on an analysis of her child’s hair and urine suggesting that the child had been exposed to the cocaine. The analysis was […]]]>
” style =”margin: 5px 15px 0 0px; border: 1px solid # 999; width: 150px;”/>
Nathan Boulanger

In 1998, Joyce Rita Hayman was convicted of criminal negligence and administration of a noxious substance, based on an analysis of her child’s hair and urine suggesting that the child had been exposed to the cocaine. The analysis was presented via expert evidence from the Motherisk Drug Testing Lab. Two reports, from the Ministry of the Attorney General (MPG) in 2015 and 2018, showed serious problems with the tests performed and used both in criminal prosecutions and in family or child protection cases.

In R. c. Hayman 2021 ONCA 242, the Ontario Court of Appeal dealt with Hayman’s convictions and admitted MAG’s reports regarding concerns about such testing. Crown counsel acknowledged the problems raised by using Motherisk experts. Acquittals have been recorded and Hayman can begin to deal with the trauma that the criminal justice system has sadly inflicted on him. As the Court of Appeal concluded, “She deserves, as she puts it, to hold her head up for the first time in a long time. “

This case underscores the importance of recognizing that as good as the Canadian criminal justice system is, it is far from perfect. Cases involving a wrongful conviction are of greatest concern to the criminal justice system. Second US President John Adams said, “It is more important that innocence be protected than that guilt be punished, because guilt and crime are so common in this world that not all of them can be punished. But if innocence itself is brought to the bar and condemned, perhaps to death, then the citizen will say: “Whether I do good or that I do evil does not matter, for the innocence itself is no protection. injustice.

The certainty and finality of the closure of a criminal case, including the conviction, is important. It can give an outcome to the victims and the accused. However, the ability to review cases, even long after the case is over, is important and necessary in cases like Hayman’s. When new evidence undermines the basis for a conviction, the matter must be reconsidered, even years later. Public confidence in the administration of justice and the rule of law demands no less.

The development of new technologies and their application to criminal cases is an ongoing process. the AI Case Study: DNA Tools for Probabilistic Genotyping in Canadian Criminal Courts (Law Commission of Ontario, June 2021) examines new algorithmic decision-making technology that is likely to become more common in the coming years. Current DNA technology, called Random Match Probability, compares DNA samples found against DNA profiles, and then reports the probability of a random match. This technology is a very reliable “gold standard” when used correctly. However, in cases where traces of DNA or mixed DNA samples are found, this can be difficult.

Probabilistic genotyping uses a computer program to use a statistical method and mathematical algorithms to reduce a group of suspects. The design of these programs is to try to determine which possible hypotheses may be more likely. However, they compare the assumptions and determine the probability rather than the facts. The difficulty is that this may not include possibilities that are not foreseen by the programmers. Criminal law deals with atypical situations, so it will be important to be creative enough to determine alternative scenarios.

It will be important to educate the trier of fact when different technologies are used, including the strengths and weaknesses of these technologies and how they differ from other similar technologies. The dangers of relying on scientific analyzes without a good understanding of their rationale are dangerous. Science should be used in criminal cases, but not without appropriate ongoing challenge and reanalysis. What disproves science is the best science, but science keeps seeing itself again, and neither can science courts.

A final interesting point in the Hayman case concerns the issue of publication bans. At the start of the appeal, a publication ban was imposed on Hayman’s name as well as his child. However, with the acquittals recorded, Hayman demanded that the publication ban be lifted. The Court of Appeal agreed to state “in light of the unjustified nature of the conviction in this case, based on what can only be described as flawed science, the least that can be done is to allow the ‘calling for the dignity of having this matter corrected now in the media if they choose to talk about it. Publication bans exist to protect certain participants in the criminal justice system. However, courts should not lose sight of who these prohibitions are meant to protect. Courts should listen to those affected by the bans and be sensitive to their interests. Publication bans should protect.

Nathan Baker is a criminal defense lawyer in Peterborough, Ont., And practices alone at Nathan Baker Law. He is particularly interested in impaired driving cases, particularly those involving drug-impaired driving and impaired navigation. Send him an e-mail at nathanbakerlaw@gmail.com.

Photo credit / Turac Novruzova
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Interested in writing for us? To learn more about how you can add your voice to The Lawyer’s Daily, contact analysis editor Peter Carter at peter.carter@lexisnexis.ca or call 647-776-6740.


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the math of a healthy middle age http://michiganparanormalencounters.com/the-math-of-a-healthy-middle-age/ http://michiganparanormalencounters.com/the-math-of-a-healthy-middle-age/#respond Sat, 03 Jul 2021 19:54:00 +0000 http://michiganparanormalencounters.com/the-math-of-a-healthy-middle-age/ In the final part of our 40s fitness math series, we reveal the lifestyles that 40s should add to their daily routine … Two minutes in a cold shower From model Elle Macpherson to fitness guru Joe Wicks, many successful people tout the benefits of a cold shower in the morning. Research has shown that […]]]>

In the final part of our 40s fitness math series, we reveal the lifestyles that 40s should add to their daily routine …

Two minutes in a cold shower

From model Elle Macpherson to fitness guru Joe Wicks, many successful people tout the benefits of a cold shower in the morning. Research has shown that cold water immersion strengthens your cardiovascular, respiratory, and musculoskeletal systems, all of which require a bit of extra care in midlife. Cold water can also increase your number of white blood cells which boost immunity. One study found that people who take cold showers are 29% less likely to make themselves sick to work, while research by Virginia Commonwealth University has found that cold showers may even help prevent depressive symptoms. Research into medical hypotheses suggests that a 20 ° C bracing is about correct. Try to brave a full two minutes in there if you can.

1.8 liters of water

Water supports your kidneys and liver, lubricates and cushions your joints, increases your mental alertness and memory, aids digestion, improves the performance of your cells, supports the transfer of nutrients and oxygen, and helps eliminate waste . But polls suggest 62 to 89% of UK adults don’t drink enough. This becomes an even bigger problem in our 40s, as we tend to “dry out” as we get older. According to the NHS, the human body contains around 70 percent water at birth, while by the time we reach old age that figure has dropped to 55 percent. There are several reasons for this: We naturally lose muscle as we age, which reduces our ability to store water. Our sweat rates, temperature control mechanisms, and kidneys become less efficient. And our thirst reflex wanes with age. So be sure to sip throughout the day. An independent review of hydration studies published in the journal Nutrients have found that a total daily water intake of less than 1.8 liters seems to be the point at which dehydration-related health problems arise. So aim for at least 1.8 liters – about eight glasses – per day.

Two hours of leisure

Whether you enjoy reading novels, gardening, or playing the piano, maintaining a range of enjoyable hobbies is the secret to a healthy 40s. Research by the University of California found that participants who devoted two hours a day to hobbies were 21% less likely to die prematurely. Challenging your brain with interesting activities helps refine your cognitive performance, increase your social interactions, and ward off illnesses. Hobbies also inject a healthy meaning into your life, which research into Psychological sciences suggests that this may work to “buffer against the risk of death” throughout quarantine and into retirement. Reading is especially powerful: A study from the University of Sussex found that reading a book can help reduce stress by up to 68%. And listening to music provides “total brain training,” according to researchers at Johns Hopkins Medicine, helping to reduce anxiety and blood pressure while improving sleep and memory.

200-300 minutes outdoors

Research from the University of East Anglia has found that spending time in the countryside helps combat stress by lowering blood pressure and HDL cholesterol, which reduces the risk of type 2 diabetes and all-cause mortality. confused. According to a research article in Scientific reports, spending 200 to 300 minutes per week outdoors in natural environments offers an optimal health boost (just over half an hour per day). It doesn’t matter if you spend everyday in a park or enjoy a long day on the weekend, as long as you achieve this goal, you will improve your physical and mental health.

Four days without alcohol

People aged 45 to 65 are more likely than any other group to drink more than the recommended alcohol limit of 14 units per week, despite an increased risk of high blood pressure, heart disease and cancer. Journal search Alcoholism: clinical and experimental research found that even lightly drinking four or more times a week can increase the risk of premature death by 20 percent. A little won’t hurt you. In fact, research in the British Medical Journal found that low to moderate wine consumption is associated with lower mortality from cardiovascular disease. But you really need four alcohol-free days a week to protect your liver – a key organ responsible for over 500 vital bodily functions, from energy production to detoxification – in mid-life.

6 p.m. end time

Working after regular business hours could kill you. New research presented at the European Cardiovascular Society’s Preventive Cardiology Congress found that people whose work hours are not in sync with their natural body clocks are at higher risk to their cardiovascular health. In fact, data from the World Health Organization suggests that long working hours kill 750,000 people a year. With the rise of home working, this is no longer just a problem for shift workers. So stick to a regular work schedule and avoid late-night emails.

Three cups of coffee

Excessive consumption of caffeine could lead to an early grave. Research has shown that high coffee consumption (more than 28 cups per week, or four cups per day) is linked to a 21% increased risk of death. But the research published in the Alzheimer’s Disease Journal suggests that moderate coffee drinking in your 40s can reduce your risk of dementia later in life by 65%, so you don’t need to give it up altogether. A paper in the Caffeine Research Journal discovered that coffee can reduce the risk of premature death by 10 percent. As always, moderation is the key, and most health organizations recommend that you eat no more than 300 mg of caffeine (about three cups) per day.

Eight hours of sleep

The 2021 UK State Sleep Survey found 54% of the UK population were unhappy with their sleep, with work pressure, financial stress and Covid-19 all having an impact . This is bad news for the health of the 40s. Journal search To sleep found that people who sleep less than seven hours a night have a 26% higher risk of dying prematurely. And a study from the University of Paris found that people who sleep less than six hours in their middle and older age have a 30% higher risk of dementia. However, those who laze in bed for more than eight hours a day also face a 17% increase in their chances of dying prematurely. So getting as close as possible to eight hours of sleep per night seems like the optimal solution. Start improving your sleep by downloading a sleep app like Pzizz, Sleep Cycle, Calm or Sleep School now.

Finally, be organized

Tidy up your desk, organize your emails, and show up on time to meetings. Being conscientious helps keep your health in your 40s, according to research from Duke University. Researchers have found that conscientious people tend to follow other good habits – such as exercising and cleaning their teeth – which makes them 27% less likely to suffer from health problems later in life, such as as obesity, high cholesterol, inflammation, hypertension and gums. disease.


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Algorithm Expands What Scientists Can Discover From Single Cells http://michiganparanormalencounters.com/algorithm-expands-what-scientists-can-discover-from-single-cells/ http://michiganparanormalencounters.com/algorithm-expands-what-scientists-can-discover-from-single-cells/#respond Thu, 01 Jul 2021 17:47:37 +0000 http://michiganparanormalencounters.com/algorithm-expands-what-scientists-can-discover-from-single-cells/ There are hundreds of transcription factors inside human cells, and years of experimental research by trial and error may be required to identify which are turned on or off in specific cell types. This is important information because these proteins could be used as potential drug targets. Previous methods developed to infer the activities of […]]]>

There are hundreds of transcription factors inside human cells, and years of experimental research by trial and error may be required to identify which are turned on or off in specific cell types. This is important information because these proteins could be used as potential drug targets.

Previous methods developed to infer the activities of transcription factors were based on messenger RNA (mRNA) encoding transcription factors. These strategies may not be representative of true biological functions because the activity of transcription factors is often regulated at the post-translational level and key changes in transcription factors may not be detected at the mRNA level.

ScRNA-seq is a powerful tool for studying transcriptomic heterogeneity between cells. However, elucidating the underlying biological functions and regulatory mechanisms (i.e. the activities of transcription factors or gene regulatory networks) of cells on the basis of these data is difficult due to the difficulties of research. integration of data from the biological context.

Most applications of scRNA-seq have focused on spatial biology, which aims to identify clusters of cells based on the proximity of individual cells in a small space. However, this analysis does not take biological function into consideration and does not help researchers discover regulatory mechanisms in subpopulations of cells.

“One of the challenges in the field is that the same genes can be turned on in a group of cells but turned off in a different group of cells within the same organ,” said Dr. Jalees Rehman, professor at the University of the Illinois at Chicago, medical school. “Being able to understand the activity of transcription factors in individual cells would allow researchers to study activity profiles in all major cell types of major organs such as the heart, brain or lungs.”

Improved scRNA-seq analysis

To address the limitations of previous scRNA-seq analysis strategies, a team of researchers from the University of Illinois at Chicago led by Rehman and Yang Dai, PhD, associate professor of bioinformatics at the university, developed the model. Bayesian inference transcription factor (BITFAM) activity.

The system combines new gene expression profile data collected from scRNA-seq with existing biological data on target genes of transcription factors. The researchers matched transcription factors to their predicted target gene set, obtained from the GTRD Chromatin Immunoprecipitation Sequencing (ChIP-seq) databases that contain more than 17,000 transcription factor samples.

A schematic overview of the BITFAM machine learning system developed by UIC researchers. User-supplied sequencing data (“normalized scRNA-Seq gene expression”) and existing data on transcription factor binding sites (“TF-target ChIP-seq gene array”) are analyzed to predict transcription factor activity (“inferred TF activity”) which can be used for a wide variety of assays. Image courtesy of Genome Research. Licensed CC BY 4.0.

The model integrates previous biological knowledge (ChIP-seq) with observed data to infer the activities of transcription factors in cell subpopulations. With this information, the system runs numerous computer simulations to find the optimal fit and predict the activity of each transcription factor in the cell.

They applied the model to several scRNA-seq datasets, including a mouse dataset that contains information on all major organs during adult homeostasis, a blood cell development dataset, and a of CRISPR interference data with 50 targeted deletions of CRISPR transcription factors.

In these settings, BITFAM was able to infer biologically significant transcription factor activities from selected well-established transcription factors with known biological functions. For example, he predicted the strong activity of T-cell acute lymphoid leukemia protein 1 (TAL1) in pulmonary endothelial cells, consistent with previous knowledge that TAL1 is an important factor in activating endothelial genes. .

“Our approach not only identifies significant activities of transcription factors, but also provides valuable information on the regulatory mechanisms of underlying transcription factors,” said lead author Shang Gao, a doctoral student in the bioengineering department of the University of Illinois at Chicago. “For example, if 80% of the targets of a specific transcription factor are activated inside the cell, this tells us that its activity is high. By providing data like this for every transcription factor in the cell. cell, the model can give researchers a good idea which ones to consider first when exploring new drug targets to work on this type of cell. ”

The authors also noted that BITFAM could be used to discover new heterogeneous subpopulations with subtle phenotypic differences driven by the regulation of transcription factors.

“This new approach could be used to develop key biological hypotheses regarding regulatory transcription factors in cells related to a wide range of hypotheses and scientific subjects,” Dai said. “This will allow us to better understand the biological functions of cells in many tissues.”

The researchers said the new system is publicly available and could be widely applied because the model can easily be combined with additional analytical methods that may be best suited for their studies, such as finding new drug targets.

Do you have a unique perspective on your research related to bioinformatics or cell biology? Contact the publisher today to find out more.

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As regulators reflect on revised nuclear medicine reporting rules, imaging advocates and others take sides http://michiganparanormalencounters.com/as-regulators-reflect-on-revised-nuclear-medicine-reporting-rules-imaging-advocates-and-others-take-sides/ http://michiganparanormalencounters.com/as-regulators-reflect-on-revised-nuclear-medicine-reporting-rules-imaging-advocates-and-others-take-sides/#respond Wed, 30 Jun 2021 02:44:59 +0000 http://michiganparanormalencounters.com/as-regulators-reflect-on-revised-nuclear-medicine-reporting-rules-imaging-advocates-and-others-take-sides/ Radiopharmaceuticals inadvertently injected into tissues rather than veins can harm patients and should fall under required national reporting guidelines, the researchers urged on Monday to Frontiers in medicine. But the call drew criticism from some advocates of the imagery. A 1980 policy from the Nuclear Regulatory Commission, which oversees the use of radioactive isotopes in […]]]>

Radiopharmaceuticals inadvertently injected into tissues rather than veins can harm patients and should fall under required national reporting guidelines, the researchers urged on Monday to Frontiers in medicine. But the call drew criticism from some advocates of the imagery.

A 1980 policy from the Nuclear Regulatory Commission, which oversees the use of radioactive isotopes in the United States, currently exempts suppliers from reporting these medical events, called extravasations.

But NRC is currently examining a petition filed last year by Lucerno Dynamics, a Cary, NC company that sells a device used to monitor injection quality, which require the quantification and reporting of certain extravasations.

In this context, the authors of the present study reviewed databases of adverse events on the subject, citing 38 examples listing diagnostic radiopharmaceutical extravasation as a factor in such events, according to Dustin Osborne, with the Department of Radiology at the University of Tennessee Graduate School of Medicine and his colleagues.

Although some questions remain, they say their research suggests “new hypotheses” related to inadvertent injections.

“Our results suggest that large extravasations may or have caused damage to patients and may irradiate patient tissues with doses that exceed medical event reporting limits and deterministic effect thresholds,” they added. June 28. “Therefore, diagnostic radiopharmaceutical injections should be monitored and extravasated tissue dosimetry should be performed in certain cases where thresholds are believed to have been exceeded.

Importantly, four of the seven authors are employed by Lucerno Dynamics.

Following last year’s petition, NRC opened a comment period garnering almost 400 responses. Many, including the NRC Advisory Committee on the Medical Uses of Isotopes, have supported the claim that there is “no clinical evidence to suggest that radiopharmaceutical extravasation is a patient safety concern.”

A number of companies and medical organizations have a similar sentiment, including the American College of Radiology.

In a statement sent to Health Imaging on Tuesday, the ACR said the NRC’s medical event requirements are a “serious regulatory mechanism,” adding that the reports are not intended to collect “irrelevant” data. .

“Therefore, ACR is registered, alongside hundreds of medical and scientific stakeholders, contrary to the company’s (Lucerno Dynamics) petition,” the college said via email. “We support the recommendations of the NRC Medical Advisory Committee that infiltrations reported to NRC as medical events should be limited to rare and aberrant extravasations that cause actual harm. “

The Society for Nuclear Medicine and Molecular Imaging offered its own comment on Tuesday.

“SNMMI strongly believes that extravasation of diagnostic radiopharmaceuticals is not a patient safety issue,” former president Alan Packard, PhD, told Health Imaging via email. “In the rare event that significant extravasation occurs, it is managed according to existing procedures under the direction of the authorized user. ”


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Scientists around the world call for open letter for investigation into origin of SARS-CoV2 http://michiganparanormalencounters.com/scientists-around-the-world-call-for-open-letter-for-investigation-into-origin-of-sars-cov2/ http://michiganparanormalencounters.com/scientists-around-the-world-call-for-open-letter-for-investigation-into-origin-of-sars-cov2/#respond Mon, 28 Jun 2021 19:39:09 +0000 http://michiganparanormalencounters.com/scientists-around-the-world-call-for-open-letter-for-investigation-into-origin-of-sars-cov2/ MORE THAN 30 scientists from around the world, including three from India, reiterated in an open letter their demand for a full investigation into the origin of SARS-CoV2. Scientists include Jamie Metzl, principal investigator, Atlantic Council, United States, Virginie Courtier, evolutionary geneticist based in Paris, and Richard Ebright, professor of chemistry at Rutgers University, United […]]]>

MORE THAN 30 scientists from around the world, including three from India, reiterated in an open letter their demand for a full investigation into the origin of SARS-CoV2.

Scientists include Jamie Metzl, principal investigator, Atlantic Council, United States, Virginie Courtier, evolutionary geneticist based in Paris, and Richard Ebright, professor of chemistry at Rutgers University, United States.

Rahul Bahulikar from Pune, Principal Scientist at BAIF Development and Research Foundation, Monali Rahalkar, Scientist, Bioenergy Group at Agharkar Research Institute, and Sk Sarif Hassan, Assistant Professor of Mathematics, Pingla Thana Mahavidyalaya, West Benga, I am the signatories of the letter which demands a scientific and forensic investigation into the plausible original hypotheses.

The couple of scientists from Pune, Dr Monali Rahalkar and her husband, Dr Rahul Bahulikar, had themselves conducted a targeted and systematic research investigation to join some of the points on the possible theory of the origin of the virus in the laboratory. This is the fourth open letter, said Dr Rahalkar.

Signing the letter released on June 28, the scientists said, “All people and nations, including China, have a vested interest in identifying the origin of the pandemic and in resolving our more major vulnerabilities. It is therefore particularly regrettable that no in-depth investigation of all plausible origins has yet been carried out and none are currently planned.

On June 12, the Director General of the World Health Organization, Dr Tedros Adhanom Ghebreyesus, said that the families of the millions of people who have died from Covid-19 “deserve to know what is the origin of this virus, in order to that we can prevent it from happening again ”.

In line with this aspiration, G7 leaders issued a joint statement the next day calling for “a timely, transparent, expert-led, science-based Phase 2 study into the origins of Covid-19, including, as the recommends the experts’ report. , in China”.

Scientists and science communicators, who called for a full investigation into the origins of the pandemic in three open letters earlier this year, welcomed the statements and again called for a full scientific and forensic investigation into all plausible original assumptions with unrestricted access to all relevant records, samples and personnel in China and, where applicable, beyond.

The letter said failure to thoroughly investigate the origins of the pandemic puts everyone and future generations at unnecessary risk, and it calls on world leaders to take a two-track approach to ensure the investigation. as complete as possible on the origins of the pandemic.


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COVID Lab Leak Theory Still Likely Wrong http://michiganparanormalencounters.com/covid-lab-leak-theory-still-likely-wrong/ http://michiganparanormalencounters.com/covid-lab-leak-theory-still-likely-wrong/#respond Sun, 27 Jun 2021 11:03:17 +0000 http://michiganparanormalencounters.com/covid-lab-leak-theory-still-likely-wrong/ Based on recent delusions from virological giants like Jon stewart and Donald Trump, a casual observer might think critical evidence has emerged to support the idea that the novel coronavirus escaped from a Chinese laboratory – or to refute the suspicion that it entered the human population at the way of countless predecessors, naturally overflowing […]]]>

Based on recent delusions from virological giants like Jon stewart and Donald Trump, a casual observer might think critical evidence has emerged to support the idea that the novel coronavirus escaped from a Chinese laboratory – or to refute the suspicion that it entered the human population at the way of countless predecessors, naturally overflowing with bats or other species. But the recent resurgence of the so-called laboratory leak theory among journalists, politicians and scientists largely outside the relevant fields means less than it seems.

What has emerged is a collective realization that the possibility of the Wuhan Institute of Virology’s involvement has not been completely refuted nor the likelihood of an overflow conclusively proven. This does not mean that the lab is a more or even a similar source. All reliable evidence still points to the same species jump that caused the previous two coronavirus pandemics. Yes, a laboratory origin remains a possibility, but it is a relatively distant origin not supported by scientific data.

This is clearly not the impression left by the last speech, however. Recent polls show that up to 60% of Americans believe the virus that causes COVID-19 has come out of a laboratory in central China.

Unfounded accusations of Chinese guilt for the virus have already fueled xenophobia and violence against Asian Americans and Pacific Islanders in the Bay Area and across the country. The recent, more common but equally reckless exaggeration of the likelihood of a lab leak portends darker consequences for too many people.

The political motives and machinations that fueled much of the dark speculation about the early origins of the virus continue to play a significant role. In its final days, the Trump administration has spread unsubstantiated information that researchers at the Wuhan lab were hospitalized with a suspicious illness in November 2019, and former officials up to and including the former president continue to seize the opportunity to shift the blame for their serious mismanagement of the pandemic.

The “theory” of laboratory leaks, which is not at all a theory according to a scientific definition, rests on a host of unfounded and circumstantial assertions. So-called genetic evidence of human manipulation continues to emerge and then fade under scrutiny. The simple location of a lab studying coronaviruses in the city where the outbreak occurred is also often cited. But the region is home to the lab due to its propensity to spread pathogens such as the first SARS coronavirus less than two decades ago.

The fact that the natural origin of the virus has not been conclusively demonstrated is also frequently and falsely presented as proof of origin in the laboratory. While it is true that the source of SARS-CoV-2 has not been found – although related bat viruses have been – this is not remarkable given the great diversity of coronaviruses, limited animal sampling and novelty of the pathogen. It took 14 years old to trace SARS-CoV-1 to a bat cave in Yunnan province, and the precise origins of viruses as familiar and deadly as HIV and Ebola have yet to be identified.

Contrary to laboratory speculation, and contrary to the suggestion of a letter in the journal Science which sparked much of the questioning, there is scientific evidence to support a natural origin. Tulane University virologist Robert Garry noted, for example, that different lineages of the virus were linked to different Wuhan wildlife markets at the start of the pandemic, a fact more compatible with the natural circulation between species.

While lab leak fever may distract from more likely assumptions, understanding the origin of the pandemic is important enough to warrant further investigation into this and other issues. Failure to communicate that this is just one issue, however, is not only regrettable but dangerous.

This commentary is from The Chronicle’s editorial board. We invite you to express your point of view in a letter to the editor. Please submit your letter via our online form: SFChronicle.com/letters.


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