Direct association between periodontal disease and outcomes related to Covid-19, according to PGI study

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The study, experts say, is the first of its kind to elucidate, based on clinical evidence and using cutting-edge MMP-8-based diagnostics, the association between active gum disease and adverse outcomes. linked to Covid -19 lower.

Periodontal disease, explained Dr. Gupta, contributes significantly to the pathophysiology of a number of systemic conditions, including respiratory disease. Several hypotheses have pointed to the possibility of a link between periodontal disease and Covid-19. (To file)

The Periodontics Unit of the Oral Health Sciences Center, in collaboration with the Department of Internal Medicine, the Department of Anesthesia and the Department of Virology, PGI, Chandigarh, carried out a study to determine the clinical association periodontitis and Covid-19.

The study, experts say, is the first of its kind to elucidate, based on clinical evidence and using cutting-edge MMP-8-based diagnostics, the association between active gum disease and adverse outcomes. linked to Covid -19 lower.

In a cohort of 82 patients positive for Covid-19, people with gum disease were found to have a seven times higher risk of requiring assisted ventilation, 36 times more likely to be admitted to a hospital , were at four times the risk. suffer from Covid-19 pneumonia and were 14 times more likely to die, compared to patients without gum disease.

The study was carried out under the supervision of Professor and Head of the Center for Oral Health Sciences, Krishan Guba. Among other authors, Dr Shipra Gupta, Dr Ritin Mohindra, Dr Mohita Singla, Dr Sagar Khera, Mr Roop Kishor Soni, Dr Poonam Kanta, Dr Kapil Goyal and Dr Mini P Singh performed a important role in the realization of research.

Dr Shipra Gupta’s research group is the first in the world to have pioneered, on the basis of clinical evidence, the association between active gum disease and adverse effects linked to Covid-19. The study, which was published in the Clinical Oral Investigations Journal, is part of an ongoing research process in which his group has been involved. Previously, they were the first in the world to report the detection of the SARS CoV-2 virus in the gum tissue. crevicular fluid, a substance emanating from around the gums. The discovery was later published in the Journal of Dental Research, one of the most prestigious journals in the field of dentistry and gave more credit to the theory of a link between oral health and Covid-19. , and also established other way of receipt and transmission of a virus.

Periodontal disease, explained Dr. Gupta, contributes significantly to the pathophysiology of a number of systemic conditions, including respiratory disease. Several hypotheses have pointed to the possibility of a link between periodontal disease and Covid-19. As compelling as it may sound, there remains a lack of actual clinical evidence to support claims that oral health is linked to the process of Covid disease. The latest published report on Dr. Gupta’s ongoing research dispelled these doubts by confirming an association between gum disease and Covid-19-related findings based on strong scientific evidence.

“It is established that a number of comorbidities, such as diabetes mellitus, obesity and those affecting the cardiovascular and respiratory systems, play an important role in determining the prognosis of Covid-19. At the same time, it is also well established in the literature that periodontal disease has definitive links with these chronic disease processes and is in good faith part of their overall pathophysiological presentation. Therefore, gum disease can potentially influence the outcome of Covid-19 both directly and indirectly, ”said Dr Gupta.

“Seeing that periodontal disease results mainly from bacterial interactions with the host, the maintenance of oral hygiene is of greater importance in the face of this new entity”, summarized
Dr Gupta.

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